Charlie Heller (Rami Malek) is a brilliant but deeply introverted decoder for the CIA working out of a basement office at headquarters in Langley whose life is turned upside down when his wife is killed in a London terrorist attack. When his supervisors refuse to take action, he takes matters into his own hands, embarking on a dangerous trek across the globe to track down those responsible, his intelligence serving as the ultimate weapon for eluding his pursuers and achieving his revenge.